Leveraging vulnerabilities created by the cancer genome to identify safe and effective therapeutic strategies for cancer patients

Our Research Focus

In the Cancer Dependency Map project, we profile large panels of cell line models to capture the heterogeneity of human cancer and link the molecular and genetic alterations of the tumors to their dependencies.

Apply new functional genomics approaches and technologies to identify new ways to map vulnerabilities at scale.

Develop experimental and computational strategies to priority therapeutic targets from depmap datasets

Investigate the molecular basis of the dependencies and triage targets to drug discovery pipelines.

Our Team

We are a multi-disciplinary team that embraces different perspectives and talents to accomplish common goals.

Barbara De Kegel

Computational Biologist

Harry Liang

Research Associate

James Neiswender

Target Discovery Project Lead

Jenny Serra-Vinardell

Research Scientist

Kirsty Wienand

Scientific Lead

Tsukasa Shibue

Target Advancement Project lead

Jason Kwon

Post Doc

Patricia Borck

Target Advancement Project lead

Francisca Vazquez

TDA Group leader, Director DepMap

Samantha Stokes

DepMap Program manager

Mike Burger

Computational scientist, Target Discovery

Lisa Cervia

Postdoc

Daniel Bondeson

Postdoc

Zoe Posner

Research Associate

Lisa Brenan

Target Discovery Project lead

Gabriel Mesa

Research Associate

Ashley Anderson

Research Associate

Megan Wong

Research Associate

Daniel Venooker

DepMap Project Manager

Chyna Betts

DepMap Senior Operations Specialist

Isha Lokurkar

Project Manager

Tate Bertea

Research Associate

Nia Lloyd

Research Associate

Anthony Lau

Research Associate II

Alumni

Edmond Chan

Postdoc

Brent Paolella

Target Advancement Project Lead

Sara Wie

Research Associate

Ashir Borah

Computational Associate

Linh (Mylinh) He

Research Associate

Nolan Bick

Research Associate II

Join Us

Scientific Lead - Cancer Dependency Map Portal, Cancer Program

Apply here

We are seeking an enthusiastic and talented candidate to lead our efforts to create an exciting next phase of the DepMap Portal. In this role, you will work closely with the DepMap scientific leadership to define the strategic vision for the DepMap portal. This will require engaging with a range of internal and external stakeholders to gather input, understand user needs, and identify key opportunities for improving the functionality, content, and usability of the portal.

Post Doc Researcher, Single Cell Genomics

Apply here

This is an ideal position for an energetic individual who wants to apply cutting-edge technology to cancer research with the ultimate goal to impact patient care. The successful candidate should enjoy systems biology approaches, thrive in collaborative environments, and have the ability to both lead and contribute to the projects. The candidate should also demonstrate strong communication and interpersonal skills and be able to interact with team members at all levels. We offer an intellectually stimulating, highly collaborative, scientifically rigorous, but socially fun and diverse environment.

Laboratory Operations Coordinator

Apply here

We seek a unique, energetic, motivated individual to join the Cancer Dependency Map team. She/he will join a talented interdisciplinary team of research scientists, computational biologists, project managers, and faculty that are working together to make DepMap a success. The successful candidate will support the expansion and maintenance of the DepMap cell line inventory and help to develop and maintain the lab infrastructure. She/he will coordinate the team’s laboratory processes and day-to-day lab operations of the DepMap lab, including, but not limited to, working with colleagues in evaluating and developing technical procedures and protocols.

Research Scientist I, Cancer Dependency Map

Apply here

We seek a unique, energetic, motivated individual to join the Cancer Dependency Map Team to lead a new large-scale academic collaboration focused on pediatric cancer. As part of this effort, you will be joining an experienced and dedicated team of experimental scientists, project managers, and computational biologists working together to transform precision cancer medicine.

Publications

Selected publications

Are CRISPR Screens Providing the Next Generation of Therapeutic Targets?

Francisca Vazquez et al.
Cancer Research
2021-12-01

Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma

Björn Stolte et al.
Journal of Experimental Medicine
2018-07-01

Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets

Joshua M. Dempster et al.
Nature Communications
2019-12-01

Predicting cell health phenotypes using image-based morphology profiling

Gregory P. Way et al.
Molecular Biology of the Cell
2021-04-01

Bridging the gap between cancer cell line models and tumours using gene expression data

Javad Noorbakhsh et al.
British Journal of Cancer
2021-03-01

Contact Us

Francisca Vazquez

Target Discovery Advancement Team
Broad Institute of MIT and Harvard
415 Main Street
Cambridge, MA 02142

vazquez@broadinstitute.org